Information for medical professionals

Medical professionals and those with an interest in medicine can find studies and reports on the use of the butterbur medicinal plant as a treatment for migraine.
We welcome suggestions and/or up-to-date additions that would complete this collection of documentation. Please send these to info@petasites.eu



English publications                                                   German publications

Neurology, 2012

Evidence-based guideline update: NSAIDs and other complementary treatments for episodic migraine prevention in adults

Holland S, Silberstein S.D

Download here (396 KB)
Nervenheilkunde, 2009

Pestwurz in der Behandlung der Migräne
(Petasites in the treatment of migraine - a review)

S. Evers

Download here (3.46 MB)
Cephalalgia, 2009

Migraine prophylaxis with herbal extracts from petasites and tanacetum versus propranol and topiramate - a comparative review of double-blind randomised controlled trials

H.C. Diener

Download here (1.77 MB)
MMW-Fortschritte der Medizin, 2009

Wirksamkeit chemischer, pflanzlicher und diätetischer Migräneprophylaktika
(Effectiveness of chemical, herbal and dietetic migraine prophylactics. An overview of randomized controlled double-blind studies).

H.C. Diener, U. Danesch

Download here (175 KB)
ScienceDirect, 2007:
Informationen zu Pestwurz (Petasites) zur Migräne Vorbeugung

Petasites hybridus extract and music therapy in the prevention of childhood migraine: An explorative study
R. Oelkers-Ax, A. Leins, P. Parzer, T. Hillecke u. a.

Download here (485.81 KB)
Nervenheilkunde, 2005:
Informationen zu Pestwurz (Petasites) zur Migräne Vorbeugung

Migräneprophylaxe mit Petasites (Pestwurz)
Klinik und Pharmakologie eines Spezialextrakts (Migraine prevention with Petasites (butterbur): Clinical history and pharmacology of a special extract)

H. Göbel, R. Pothmann, R. Bauer, U. Danesch

Download here (1.55 MB)
Planta Med, 2005:

Petasites hybridus Extracts in vitro COX-2 and PGE2 Release by Direct Interaction with the Enzyme and by Preventing p42/44 MAP Kinase Activation in Rat Primary Microglial Cells
B. L. Fiebich, M. Grozdeva, S. Hess, M. Hüll u. a.

Download here (272 KB)
Neurology, 2004:
Informationen zu Pestwurz (Petasites) zur Migräne Vorbeugung

Petasites hybridus root (butterbur) is an effective preventive treatment for migraine
R. B. Lipton, H. Göbel, K. M. Einhäupl, K. Wilks u. a.

Download here (1.04 MB)
European Neurology, 2004:
Informationen zu Pestwurz (Petasites) zur Migräne Vorbeugung

The First Placebo-Controlled Trial of a Special Butterbur Root Extract for the Prevention of Migraine: Reanalysis of Efficacy Criteria
H. C. Diener, V. W. Rahlfs, U. Danesch

Download here (183.36 KB)


Research Submission, 2004
Informationen zu Pestwurz (Petasites) zur Migräne Vorbeugung

Migraine Prevention in Children and Adolescents: Results of an Open Study with a Special Butterbur Root Extract
R. Pothmann, U. Danesch

Download here (196 KB)